ICGC PedBrainTumor




  • Kool, M., Jones, D.T.W. Jäger, N., Northcott, P.A., Pugh, ..., Korshunov, A., Eils, R., Wechsler-Reya, R.J.*, Lichter, P.,* Pfister, S.M.*. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened-inhibition. Cancer Cell. 2014 Mar 17;25(3):393-405. |  doi: 10.1016/j.ccr.2014.02.004


  • Hovestadt, V.,* Jones, D.T.W.*, Picelli, S., Wang, W., Kool, M., ..., Korshunov, A., Zapatka, M., Radlwimmer, B.*, Pfister, S.M.*, Lichter, P.*. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 2014 Jun 26;510(7506):537-41. |  doi: 10.1038/nature13268


  • Northcott, P.A.*, Lee, C.*, Zichner, T.*, Stütz, A.M., Erkek, S., ..., Taylor, M.D., Lichter, P.*, Korbel, J.O.*, Wechsler-Reya, R.J.*, Pfister, S.M.*. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 2014 Jul 24;511(7510):428-34. |  doi: 10.1038/nature13379


  • Sturm, D., Bender, S., Jones, D.T.W., Lichter, P., Grill, J., ..., Iavarone, A., Aldape, K., Brennan, C.W., Jabado, N., Pfister, S.M. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer . 2014 Feb;14(2):92-107.  |  doi: 10.1038/nrc3655.



  • Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, ..., Lichter P, Monje M, Plass C, Cho YJ, Pfister SM. Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas. Cancer Cell. 2013 Nov 11;24(5):660-72. | doi: 10.1016/j.ccr.2013.10.006


  • Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, ..., Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R. Hypermutation of the inactive x chromosome is a frequent event in cancer. Cell. 2013 Oct 24;155(3):567-81. | doi: 10.1016/j.cell.2013.09.042


  • Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, …, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR. Signatures of mutational processes in human cancer. Nature. 2013 Aug 22;500(7463):415-21. | doi: 10.1038/nature12477


  • Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, …, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet. 2013 Aug;45(8):927-32. | doi: 10.1038/ng.2682


  • Lambert SR, Witt H, Hovestadt V, Zucknick M, Kool M, ..., Fontebasso AM, Lichter P, Pfister SM, Collins VP, Jones DT. Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma. Acta Neuropathol. 2013 Aug;126(2):291-301. | doi: 10.1007/s00401-013-1124-7


  • Hovestadt V, Remke M, Kool M, Pietsch T, Northcott PA, ..., Korshunov A, Lichter P, Taylor MD, Pfister SM, Jones DT. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathol. 2013 Jun;125(6):913-6. | doi: 10.1007/s00401-013-1126-5


  • Rieber N, Zapatka M, Lasitschka B, Jones D, Northcott P, ..., Taylor M, Lichter P, Pfister S, Wolf S, Brors B, Eils R. Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies. PLoS One. 2013 Jun 11;8(6):e66621. | doi: 10.1371/journal.pone.0066621 .


  • Jones DT, Northcott PA, Kool M, Pfister SM. The role of chromatin remodeling in medulloblastoma. Brain Pathol. 2013 Mar;23(2):193-9. |doi: 10.1111/bpa.12019. Review  


  • Fontebasso AM, Liu XY, Sturm D, Jabado N. Chromatin remodeling defects in pediatric and young adult glioblastoma: a tale of a variant histone 3 tail. Brain Pathol. 2013 Mar;23(2):210-6. | doi: 10.1111/bpa.12023. Review



  • Northcott PA, Jones DT, Kool M, Robinson GW, Gilbertson RJ, Cho YJ, Pomeroy SL, Korshunov A, Lichter P, Taylor MD, Pfister SM.Medulloblastomics: the end of the beginning.Nat Rev Cancer . 2012 Dec;12(12):818-34. | doi: 10.1038/nrc3410. Review


  • Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, ..., Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM.Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.  Cancer Cell . 2012 Oct 16;22(4):425-37. |doi: 10.1016/j.ccr.2012.08.024


  • Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, ..., Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ.Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 2012 Aug 2;488(7409):106-10.| doi: 10.1038/nature11329

  • Jones DT, Jäger N, Kool M, Zichner T, Hutter B, ..., Korbel JO, Korshunov A, Eils R, Pfister SM, Lichter P.Dissecting the genomic complexity underlying medulloblastoma.Nature. 2012 Aug 2;488(7409):100-5. | doi: 10.1038/nature11284

  • Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, ..., Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD.Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 2;488(7409):49-56. |doi: 10.1038/nature11327

  • Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, ..., Gilbertson RJ, Pomeroy SL, Taylor MD, Lichter P, Pfister SM.Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol . 2012, 123(4):473-84. | doi:10.1007/s00401-012-0958-8

  • Northcott PA, Korshunov A, Pfister SM, Taylor MD.The clinical implications of medulloblastoma subgroups.Nat Rev Neurol. 2012, 8, 340-351. | doi:10.1038/nrneurol.2012.78

  • Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, ..., Tabori U,  Plass C, Majewski J, Pfister SM, Jabado N.Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.Nature. 2012, 482(7384):226-31. | doi:10.1038/nature10833

  • Rausch T, Jones DT, Zapatka M, Stütz AM, Zichner T, ..., Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO.Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations. Cell. 2012, 148, 51-79. |doi:10.1060/j.cell.2011.12.013




  • The International Cancer Genome Consortium. International network of cancer genome projects.  Nature. 2010, 464, 993-998. |doi: 10.1038/nature09167



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